silverion-slide

Download Presentation

User3

User2

Technical Data

Characterization
SILVÉRION™ 2400 is a patented antimicrobial based on stabilized silver ion complex produced by a unique electrochemical process with silver and citric acid.
Chemical nature
Water soluble silver salt of citric acid.
Structure
INCI Name
Citric acid (and) silver citrate
Product form
Colorless, low viscous liquid
Shelf Life
3 years
Features/benefits
SILVÉRION™ 2400 provides a broad spectrum antimicrobial activity and is effective against unwanted skin bacteria and pathogenic microorganisms. Its fast killing activity makes SILVÉRION™ 2400 an effective antimicrobial for personal care products.
Applications
Deodorant active for Personal Care products
Antimicrobial active for Personal Care products

Due to different national regulations for antimicrobials, biocides and preservatives, the local registration status has to be considered.

Guidelines for use
Personal care products 0.1 – 0.3%
SILVÉRION™ 2400 shows good compatibility in most formulations at pH
Instructions for Incorporation
SILVÉRION™ 2400 is highly water soluble and easy to incorporate into the aqueous phase of gels, surfactants and emulsions made by a cold process. In the manufacturing of emulsions produced by hot processes, the antimicrobial active should preferably be added to the final formulation after emulsion has cooled down. For formulations sensitive to acids, SILVÉRION™ 2400 can be pre-neutralized prior to addition to the product. Exposure of SILVÉRION™ 2400 to pH values higher than 7 and temperatures above 50C should be avoided in order to achieve optimal formulation stability. High salt concentrations can reduce the bactericidal activity whereas anionic surfactants in a concentration of 0.03% to 1% increase the biocidal efficacy of SILVÉRION™ 2400.
Broad Spectrum Efficacy Minimum Inhibitory Concentration (MIC) of SILVÉRION™ 2400
Microorganism MIC ofSILV~RIONTM 2400(%)
GRAM-POSITIVE BACTERIA
Corynebacterium minutissimum ATCC 23348 0.12
Corynebacterium xerosis ATCC 373 0.12
Micrococcus luteus ATCC 10240 0.08
Staphylococcus aureus ATCC 6538 0.16
Bacillus subtilis ATCC 6633 0.16
GRAM NEGATIVE BACTERIA
Escherichia coli ATCC 10536 0.08
Enterobacter gergoviae ATCC 33028 0.16
Klebsiella pneumoniae ATCC 4352 0.16
Proteus mirabilis ATCC 14153 0.16
Pseudomonas aeruginosa ATCC 15442 0.16
Pseudomonas fluorescens ATCC 17826 0.16
YEASTS & MOLDS
Aspergillus niger ATCC 16404 0.50
Candida albicans ATCC 10231 0.12
Malassezia furfur DSM 6171 0.25
Trichophyton mentagrophytes ATCC 9533 0.50
Strong Reduction of Bacteria Involved in Body Malodor Formation by SILVÉRION™ 2400
SILVÉRION™ 2400 prevents the formation of body malodor by fast reduction of bacteria which metabolize human sweat. A study with a roll-on emulsion containing 0.3% SILVÉRION™ 2400 showed a 99.999% reduction (i.e. 5 log) of Corynebacterium minutissimum within 5 minutes.

Test bacteria: Corynebacterium minutissimum ATCC 23348. Formulation: Deodorant roll-on containing 0.3% SILVÉRION™ 2400. Placebo: Deodorant roll-on without SILVÉRION™ 2400. Protocol: EN1040 (5 minute contact time; 90% test product concentration).

Bacterial Activity of 0.3% SILVERION 2400
Bacterial activity of 0.3% SILVÉRION™ 2400

The deoderizing activity of a formulation containing 0.3% SILVÉRION™ 2400 was proven under in-vivo test conditions on 18 volunteers.

A 5 day in-use study was SILVÉRION™ 2400 performed with volunteers using a deodorant spray with 0.3% SILVÉRION™ 2400 and the same formulation without active. 24 hours after the last application, volunteers gave their ratings on preference. 50% preferred the formulation with 0.03% SILVÉRION™ 2400. No volunteer preferred the placebo.


Activity of 0.3% SILVÉRION™ 2400

SILVÉRION™ 2400 is an effective antimicrobial active
With its strong antibacterial effect, SILVÉRION™ 2400 is perfectly suitable for skin cleansing products like liquid soaps, body showers, shampoos, wipes and baths as well as skin care products such as creams, lotions and gels.

A suspension test according to EN1040 was performed to demonstrate the strong antibacterial effect of a liquid hand soap formulation containing 0.1% and 0.3% SILVÉRION™ 2400. The strain Staphylococcus aureus ATCC 6538 was exposed for 5 minutes contact time to the formulation (90% concentration).

SILVERION 2400 Log Bacterial Reduction

Activity of SILVÉRION™ 2400 in wet wipe formulation
A suspension test according to EN1040 was performed with a wet wipe liquid with 15 minutes contact time at 80% test product concentration. The test product contained 0.3% SILVÉRION™ 2400 . Test organisms used were Staphylococcus aureus ATCC 6538, Pseudomonas aeruginosa ATCC 15442, Escherichia coli ATCC 10536 and Candida albicans ATCC 10231.

 wet wipe

Social Media Links

Facebook

Contact us

  • Phone: 619.596.8600
  • Fax: 619.596.8790
  • Email: This email address is being protected from spambots. You need JavaScript enabled to view it.
  • Web: www.purebio.com